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Amiodarone, tacrolimus, cyclosporine, carbamazepine, phenytoin, and quinidine may increase respective CYP3A4-substrate what is the dosage for flagyl levels; monitoring of plasma concentrations of CYP3A4 substrates may be necessaryMetronidazole decreases clearance of 5-fluorouracil and may therefore cause 5-fluorouracil toxicityMetronidazole may potentiate effects of vecuronium There are no adequate and well-controlled studies of in pregnant women; there are published data from case-control studies, cohort studies, and 2 meta-analyses that include more than 5000 pregnant women who used metronidazole during pregnancy; many studies included first trimester exposures; one what is the dosage for flagyl showed increased risk of cleft lip, with or without cleft palate, in infants exposed to metronidazole in utero; however, these findings were not confirmed Metronidazole crosses placental barrier and its effects on human fetal organogenesis are not known; reproduction studies have been performed in rats, rabbits and mice at doses similar to maximum recommended daily dose based on body surface area comparisons; there was no evidence of harm to fetus due to metronidazole; healthcare provider should carefully consider potential risks and benefits for each specific patient before prescribing therapy Metronidazole is present in human milk at concentrations similar to maternal serum levels, and infant serum levels can be close to or comparable to infant therapeutic levels Because of potential for tumorigenicity shown for metronidazole in mouse and rat what is the dosages for flagyl, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account importance of drug to mother; alternatively, a nursing mother may choose to pump and discard human milk for duration of metronidazole therapy, and for 24 hours after therapy ends and feed her infant stored human milk or formula There are published data from case-control studies, cohort studies, and 2 meta-analyses that included more than 5000 pregnant women who used metronidazole systemically during pregnancy Many studies included first trimester exposures One study showed an increased risk of cleft lip, with or without cleft palate, in infants exposed to metronidazole in utero; however, these findings were not confirmed In addition, more than 10 randomized, placebo-controlled clinical what is the dosages for flagyl that together enrolled over 5000 pregnant women assessed the possible effect of systemic antibiotic treatment including with metronidazole for bacterial vaginosis on the incidence of preterm delivery; most studies did not show an increased risk of congenital anomalies or other adverse fetal outcomes following metronidazole exposure during pregnancy Three studies conducted to assess the risk of infant cancer following systemic metronidazole exposure during pregnancy did not show an increased risk; however, the ability of these studies to detect such a signal was limitedA: Generally acceptable.doi.

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Other drugs may affect metronidazole vaginal, including prescription and over-the-counter medicines, vitamins, and how to prescribe metronidazole products. Not all possible drug interactions are listed here.0% to 1. 1% P. he proportion of the phylum Proteobacteria did not show significant alteration Figure 1 However, the family Enterobacteriaceae, belonging to the class Gammaproteobacteria and order Enterobacteriales, showed a significant increase following metronidazole administration 0.

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Metronidazole is also indicated for the treatment of bacterial vaginosis caused by Gardnerella vaginalis. Despite 45 years of extensive use, metronidazole remains the criterion standard for the management and prophylaxis of how to prescribe metronidazole infections Figure 1 Metronidazole is effective for the management of anaerobic infections, such as intra-abdominal infections, gynecologic infections, septicemia, endocarditis, bone and how to prescribe metronidazole infections, central nervous system infections, respiratory tract infections, skin and skin-structure infections, and oral and dental infections.ve been done with it for about a week, and the side effects did not seem to improve, but have only gotten worse.


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