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Clinical data
Pronunciation/ r ə ˈ b ɛ p r ə ˌ z ɔː l /
Trade namesAcipHex, Pariet, others
License dataUS   FDA: Rabeprazole
Pregnancy categoryUS: C (Risk not ruled out) [1]
Routes of administrationBy mouth
Drug classProton pump inhibitor [2]
ATC codeA02BC04 ( WHO )
Legal status
Legal statusUK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability52% [2]
Protein binding96.3% [3]
MetabolismCYP2C19 and CYP3A4 in the liver [2]
Metabolitesthioether carboyxlic acid metabolite, thioether glucuronide metabolite, sulfone metabolite [3]
Elimination half-life~1 hour [2]
Excretion90% via kidney as metabolites [4]

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Caution is advised if proton-pump inhibitors are used concomitantly with ritonavir-boosted saquinavir, and patients should be monitored for saquinavir toxicity. PPIs omeprazole, lansoprazole, rabeprazole, pantoprazole, es- omeprazole, nonselective NSAIDs nsNSAIDs acetylsalicylic acid 325 mg ... Omeprazole.

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However, the background rabeprazole dr 20 mg in the U. general population of major birth defects is 2 to 4% and of miscarriage is 15 to 20% of clinically recognized pregnancies.Individuals who are at risk for osteoporosis-related fractures should receive an adequate intake of calcium and vitamin D and should have their bone health assessed and managed according to current standards of care.

Hypomagnesemia, symptomatic and asymptomatic, has been reported rarely in patients receiving rabeprazole dr 20 mg therapy for at least 3 months or, in most cases, for longer than one year with proton-pump inhibitors, including rabeprazole.

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The pKa the pH at which 50% of the drug becomes positively charged of rabeprazole is around 5.Avoid combinations; the risk of the interaction outweighs the benefit.

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Daily treatment with any acid-suppressing medications over a long period of time e. longer than 3 years may lead to malabsorption of cyanocobalamin vitamin B-12 caused by hypo- or achlorhydria.A significant portion rabeprazole dr 20mg rabeprazole is metabolized via systemic nonenzymatic reduction to a thioether compound.

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Rabeprazole dr 20 mg with your doctor about this risk. If you use rabeprazole for longer than 3 years, you could develop a vitamin B-12 deficiency.Dexilant was originally known as Kapidex. Information on side effects from studies where a PPI is compared to a placebo shows that the most common side effects are headache, abdominal pain, bloating, diarrhea and nausea.

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The adverse reactions reported without regard to relationship to diarrhea 4. nausea 4.The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Rabeprazole dr 20mg you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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Aciphex may also interact with diuretics water pills and cyclosporine. Nexium may also interact with diazepam, clopidogrel, cilostazol, erlotinib, iron-containing medicines ferrous fumarate, ferrous gluconate, ferrous sulfate, and others mycophenolate mofetil, rifampin, St.

John's wort, tacrolimus, and Rabeprazole dr 20 mg medications.Increases in INR andprothrombin time may lead to abnormal bleeding and even deathsee WARNINGS AND PRECAUTIONS. Monitor INR and prothrombin time.

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Bone Fracture: Long-term and rabeprazole sod dr tabs 20mg daily dose PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, or spine 5. Cutaneous and Systemic Lupus Erythematosus: Mostly cutaneous, new onset or exacerbation of existing disease; discontinue rabeprazole and refer to specialist for evaluation 5.ell your doctor if your condition persists or worsens.

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Following discontinuance of the proton-pump inhibitor, hypomagnesemia resolved within a median of one week; upon rechallenge, hypomagnesemia recurred within a median of rabeprazole dr 20 mg weeks. In patients expected to receive long-term therapy with a proton-pump inhibitor or in those receiving a proton-pump inhibitor concomitantly with digoxin or drugs that may cause hypomagnesemia e.A significant portion of rabeprazole is metabolized via systemic nonenzymatic reduction to a thioether compound.

Rabeprazole is also metabolized to sulphone and desmethyl compounds via cytochrome P450 in the rabeprazole dr 20 mg.

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The safety and effectiveness of a different dosage form and dosage strength of rabeprazole has been established in pediatric patients 1 to 11 years for the treatment of GERD.hile most patients achieve ulcer healing after 4 weeks, some patients may need an additional course of therapy to achieve ulcer healing.

Use: Short-term treatment for the healing and symptomatic relief of duodenal ulcers Comment: If rabeprazole dr 20 mg are not healed after 8 weeks, treatment for another 8 weeks may be considered.

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For pediatric patients 1 year to less than 12 years of age consider another rabeprazole formulation. The rabeprazole sod dr 20 mg and effectiveness of a different dosage form and dosage strength of rabeprazole has been established performed.The recommended dosage of rabeprazole sodium delayed-release tablets is 20 mg once daily.

Two U. multicenter, double-blind, placebo controlled studies were conducted in 316 adult patients with daytime and nighttime heartburn.

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Infant formula, apple juice, or pediatric electrolyte solution rabeprazole at oral doses up to 100 mg/kg/day did not produce any increased tumor occurrence.If required, administer gefitinib 12 hours after administration of the PPI or 12 hours before the next dose of the PPI. Closely monitor clinical response to gefitinib.


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